APOE and atherosclerosis: The ApoE deficient mice are an idoneous experimental model for the study of atherosclerosis [15], because it is unable to carry out the reverse cholesterol transport, since it lacks the gene coding for apolipoprotein E. The lack of this gene involves accumulation of lipids at the luminal level in blood vessels, developing lesions in the microvasculature and showing total blood cholesterol levels ≥500 mg/dL, mostly VLDL and remaining chylomicrons, after administering a normal diet [16].