CD40LG and atherosclerosis: Fuentes et al. demonstrated for the first time that guanosine from Solanum lycopersicom possessed antiplatelet (secretion, spreading, adhesion and aggregation) activity induced by ADP as well as collagen in vitro and inhibited platelet inflammatory mediator of atherosclerosis (sCD40L), while depression of CD40L expression can prevent thromboembolic-related disorders [131].