The present study demonstrated that curcumin effectively protects the ADSCs from oxidative stress via regulation of PTEN/Akt/p53 and HO-1 signal proteins and promotes the VEGF release from ADSCs, which facilitated enhancement of cardiac function, improvement of cells retention, modification of the ischemic microenvironment, and decrease of fibrosis in MI hearts. Here, TP53 is linked to myocardial infarction.