Of the 128 diabetes patients not treated with metformin 67 (27.8%) were treated with diet alone, 35 (14.5%) with sulfonylurea alone, 23 (9.5%) with insulin alone and 1 (0.4%) with sulfonylurea and dipeptidyl peptidase-4 inhibitor (sitaglipin). The gene discussed is INS; the disease is diabetes mellitus.