In wild-type mice, mast cells responding to dengue virus infection upregulated chemokine expression (RANTES/CCL5, SDF-1/CXCL12, and fractalkine/CX3CL1), and mediated recruitment of NKT cells (CD3+NK1.1+) into the skin at sites of dengue virus infection (231). This evidence concerns the gene CX3CL1 and dengue disease.