Interest in CD44 increased considerably, when it was noted that the insertion of alternatively spliced exon products in the CD44 standard or CD44 hematopoietic isoform (CD44s) strikingly affects the molecules function, such that expression of CD44 variant isoforms (CD44v) induces a metastatic phenotype in locally growing tumor cells (2, 3). The gene discussed is CD44; the disease is neoplasm.