Numerous candidate genes could be added to this list by including polymorphisms that have been shown to have a marginally significant association with DN, and gene expression studies that have associated DN with changes in expression levels of miRNAs and members of the NF-κB, TGF-β1 and complement pathways (19, 81, 85, 108–113). This evidence concerns the gene TGFB1 and liver dysplastic nodule.