ESRRB and Familial prostate cancer: By contrast, reduced ERRβ and ERRγ expression in some prostatic carcinomas has been reported (77), and overexpression of ERRβ or ERRγ results in the suppression of cell proliferation in both androgen-sensitive and insensitive prostate cancer cells, suggesting that these receptors present antiproliferative or tumor-suppressing functions in prostate cancer (46, 49).