NOTCH1 and posterior cortical atrophy: Mechanism dissection using ChIP and luciferase assays found that TR4 transcriptionally regulates the oncogene EZH2. EZH2 may then regulate the expression of its downstream key metastasis-related genes including NOTCH1, TGFβ1, SLUG, and MMP9. Adding back EZH2 in the TR4–shRNA PCa cell lines can partially interrupt the TR4–shRNA suppression effect on PCa cells invasion.