Adjusting for clinical determinants, among all ratios examined, only increase in MMP9/TIMP1 and MMP9/TIMP2 ratios remained significantly associated with sICH (p = 0.005, p = 0.003, respectively), whereas only relative increase in MMP9/TIMP1 ratio was significantly associated with relevant HT (p = 0.006) with a trend toward significance for MMP9/TIMP2 ratio (p = 0.007). This evidence concerns the gene TIMP2 and hematocrit.