SLC8A3 and Cerebral ischemia: Recent findings demonstrated that the two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, which are involved in several pathophysiological aspects of cerebral ischemia, can be included among the members of the growing family of the mediators involved in the ischemic brain tolerance due to their ability to regulate neuronal calcium homeostasis (Figure 1).