RHOT1 and amyotrophic lateral sclerosis: Given the additional fact that Miro1 is reduced in young SODG93A mice well preceding disease onset and the fact that mice with Miro1 deficiency show motor deficits (Nguyen et al., 2014), all these studies together suggest that Miro-1-mediated mitochondrial movement deficits might be the cause rather than the consequence of ALS.