SOD1 and amyotrophic lateral sclerosis: Consistently, impaired mitochondrial movement and altered mitochondrial distribution were noted in motor neurons expressing ALS-associated mutant SOD1 G93A or TDP-43 M337V in vitro and in mice (De Vos et al., 2007; Bilsland et al., 2010; Wang et al., 2013; Magrané et al., 2014).