Brains affected by AD suffer from a severe decline of the cholinergic system (Terry and Davies, 1980) and p75NTR is thought to be involved in the pathogenesis of AD, including formation of tangles in the process of AD, mediating amyloid-β toxicity and stimulating amyloidogenesis (Hu et al., 2002; Chakravarthy et al., 2012). Here, NGFR is linked to Alzheimer disease.