The case for Teneurin-2 is less clear: the 5q34 region associated with intellectual disabilities (Paoloni-Giacobino et al., 1999; Abuelo et al., 2000; Tucker and Chiquet-Ehrismann, 2006) contains at least 20 genes, including Teneurin-2 but also contains Slit3 and two GABA neurotransmitter receptors, genes with known roles in axon guidance and nervous system function. The gene discussed is TENM2; the disease is Intellectual disability.