In this context, we have shown here that CRF and 5-HT receptors, which are implicated in stress, anxiety and depression in many regions (Aghajanian and Davis, 1975; Kahn et al., 1988; Eison, 1990; Davis, 1992; Arborelius et al., 1999; Naughton et al., 2000; Muller et al., 2003; Merali et al., 2004; Risbrough and Stein, 2006) have profound effects in the PC. Here, CRH is linked to major depressive disorder.