ABO and Cognitive impairment: Blocking TNFR1 signaling or alleviating brain ER stress through the use of chemical chaperones abrogate AβO-induced cognitive impairment (Lourenco et al., 2013), in accordance with findings in AD transgenic models (He et al., 2007; McAlpine et al., 2009; Ricobaraza et al., 2009, 2012).