PRNP and memory impairment: Interestingly, exposure to AβOs recruits PrPC molecules to the neuronal surface (Caetano et al., 2011), consistent with functional interaction between oligomers and PrPC triggering signaling pathways to cause memory impairment (Gimbel et al., 2010; Um et al., 2012, 2013; Peters et al., 2015).