MAPT and Alzheimer disease: Tau pathology has further been shown to cause brain oxidative and ER stress in animal models of AD (Dias-Santagata et al., 2007; Abisambra et al., 2013; Frost et al., 2014) and, of clinical relevance, Aβ-linked cortical volume loss only develops in the presence of p-tau, further connecting amyloid to tau pathology (Desikan et al., 2011).