MAPT and Alzheimer disease: A subset of neurons in the DRG were also labeled with pFTAA and, as in the brain, this labeling coincided with immunolabeling with HT7 or the MC1 antibody (Figure 1D), which detects a conformational change in tau that is associated with neurofibrillary tangles in human AD brains (Weaver et al., 2000) and is only evident in DRG neurons from P301S tau mice when they are also AT100+ve (Mellone et al., 2013).