MAPT and early-onset autosomal dominant Alzheimer disease: However, insoluble hyperphosphorylated filamentous tau forms the neurofibrillary tangles (NFTs) and Pick bodies that are diagnostic hallmarks of numerous neurodegenerative diseases including Alzheimer's disease (AD), Pick's disease, frontotemporal dementia with Parkinsonism linked to chromosome 17, progressive supranuclear palsy and cortical basal degeneration (Spillantini and Goedert, 2013).