Given numerous reports underlining reduced expression of Bax and increased expression of Bcl2 in many drug-resistant tumor cells and recent reports showing the ability of 4-aryl-4H-chromenes family to induce procaspase-9 cleavage and thus activation we hypothesized that induction of mitochondrial apoptosis pathway by chromene compounds might be mediated through the Bcl2 and Bax proteins. This evidence concerns the gene BCL2 and neoplasm.