Given numerous reports underlining reduced expression of Bax and increased expression of Bcl2 in many drug-resistant tumor cells and recent reports showing the ability of 4-aryl-4H-chromenes family to induce procaspase-9 cleavage and thus activation we hypothesized that induction of mitochondrial apoptosis pathway by chromene compounds might be mediated through the Bcl2 and Bax proteins. Here, BAX is linked to neoplasm.