In transitional cell carcinoma of the bladder, several studies revealed that methylated genes such as CDH1, FHIT, LAMC2, RASSF1A, TIMP3, SFRP1, SOX9, PMF1, and RUNX3 are associated with tumor characteristics and prognosis [3, 5, 15]. The gene discussed is LAMC2; the disease is neoplasm.