In addition, two genes neighbouring ZtCBR2 in the Z. tritici genome, annotated as a predicted CYP, ZtCYP-24 (GenBank accession: XP_003853538.1), and a predicted hydroxyacyl coA dehydrogenase (GenBank accession: XP_003852872.1), showed similar expression profiles to ZtCBR2. Both genes exhibited a significant up-regulation in PDB (p < 0.05) and up-regulation on day four of infection (p < 0.05) either relative to during growth in CDB for ZtCYP-24 or to all other infection time points for the hydroxyacyl CoA dehydrogenase (Fig. 2B). Here, PPIG is linked to infection.