SMARCB1 and cancer: For example, germline alterations (mutations or deletions) of the gene coding for INI1 (also referred to as hSNF5 due to its similarity to the yeast protein SNF5, SMARCB1, or BAF47), one of the core subunits of the complex, predispose individuals to rhabdoid tumors, highly aggressive cancers primarily affecting young children (Versteege et al., 1998).