IL1B and autoinflammatory syndrome: Based on the consistent body of evidence of the pathogenic role of inflammasome-dependent release of IL-1beta in patients with asbestosis and related systemic autoimmune disease, we decided to treat our patient with canakinumab, a specifically targeted anti-IL-1beta antibody, which has been licensed for the treatment of inflammasome-mediated autoinflammatory syndromes [23].