These include studies in Drosophila where dS6K is required for starvation-induced autophagy [14], in mammalian cells where resveratrol-induced inhibition of p70S6K impairs the autophagic response [15], and in colorectal cancer cells where p70S6K positively regulates 6-thioguanine-induced autophagy [16]. The gene discussed is RPS6KB1; the disease is colorectal cancer.