Due to small blood samples, we did not examine the cytotoxic activity of NK cells from AS patients, and recent study conducted in CD160-deficent mice demonstrates that CD160 controls the IFN-γ production of NK cells without affecting their cytotoxicity in tumor models [37], suggesting that CD160 on NK cells can intensify the inflammation independent of NK’s cytotoxicity. The gene discussed is CD160; the disease is neoplasm.