Considering the possible direct biological effect of CD5 on B cells, namely its role as a negative regulator of B cell signaling, its influence on the ERK, PI3K, and calcineurin pathways as well as survival stimulation through autocrine IL10-related loops and the predominant expression of integrin beta-1 on the tumor cells, CD5 seems to be of probable functional and therapeutic importance for targeted approaches [40, 54–56]. Here, CD5 is linked to neoplasm.