Finally, factors predicting inferior OS were failure to achieve response according to international criteria, failure to achieve complete combined metabolic and morphologic (but not only metabolic) response (p values for all <0.005), expression of FOXP1 in >50 % of tumor cells (p < 0.005; Fig. 2d), expression of cyclin E in >12 % of tumor cells (p = 0.005), expression of CD5 (p = 0.007), expression of bcl2 in >70 % of tumor cells (p = 0.016), expression of CD95 in any tumor cell (p = 0.018), and expression of pSTAT3 in >17 % of tumor cells (p = 0.025). Here, CCNE1 is linked to neoplasm.