In addition, CD5-positive cases seem to overexpress bcl2, CARD11, CCND2, and FOXP1 at the protein and mRNA level and to be more rich in c-Rel, p65, and pSTAT3 [53], all known to identify DLBCL patients at risk; this study [53] also confirmed [48] downregulation of cellular adhesion genes in such instances. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.