According to univariate analysis, several factors were correlated with overall survival of 112 CRC patients, including Rab27A protein expression (p = 0.001), tumor differentiation (p = 0.001), serum CEA level (p = 0.006), T (p = 0.004), M (p = 0.005) and TNM stage (p = 0.003). The gene discussed is RAB27A; the disease is colorectal carcinoma.