Consistent with anti-metastatic property of Yukyung Karne, further our gelatin zymography studies also indicated a marked reduction in the activity of key enzymes MMP2/9 (Fig. 4a) that are involved in the cleavage of ECM components during tumor invasion and metastasis and are abundantly expressed in various malignant cancers [32, 33]. Here, MMP2 is linked to neoplasm.