In addition, the assay results and comparison of blood samples collected from mice a day prior to targeted drug treatment and 5 days after targeted drug treatment by ELISA method showed that serum phospho-CSE1L levels declined 5 days after vemurafenib and sunitinib treatment in all five mice, whereas serum phospho-CSE1L levels increased 5 days following 1 mg/kg of lapatinib treatment in all four mice bearing A375 melanoma xenografts (Figure 5). The gene discussed is CSE1L; the disease is melanoma.