Interestingly, the p110α catalytic subunit of phosphatidylinositide 3 (PI3) kinase appeared among the most strongly down-regulated genes upon TBL1 deficiency, the effect of which was conserved between human and mouse pancreatic cancer cells (Fig3B; Supplementary Fig S3C and E and S6A and B) and was specific for the p110α subunit as other PI3 kinase subunits remained unchanged (Supplementary Fig S6C). The gene discussed is TBL1Y; the disease is pancreatic neoplasm.