Importantly, siRNA- or shRNA-mediated knockdown of TBL1 in murine pancreatic cancer cells (Panc02 and Panc8680) also reduced cell proliferation (Fig2A and B; Supplementary Fig S3B), underlining the conclusion that TBL1 fulfills a conserved growth regulatory function in both human and murine pancreatic cancer cells. This evidence concerns the gene TBL1Y and familial pancreatic carcinoma.