TBL1Y and pancreatic ductal adenocarcinoma: siRNA-mediated knockdown of TBL1 in human pancreatic ductal adenocarcinoma (Capan-1) cells (Supplementary Fig S3A, C and D) led to a significant reduction in cell proliferation and cell numbers compared with control siRNA-transfected cells as demonstrated by EdU incorporation and cell counting (Fig2A and B).