Together with the in vitro data, these observations indicate that TBL1 represents a direct transcriptional regulator of p110α PI3 kinase and thus controls an essential node in the intracellular pro-tumorigenic network in PDAC (Eser et al, 2013) that may explain in some parts the multi-facetted impact of TBL1 on pancreatic cancer cell behavior. The gene discussed is TBL1Y; the disease is familial pancreatic carcinoma.