Noteworthy, the absence of changes in Wnt target gene expression upon TBL1 deficiency (Supplementary Table S2) suggested that this previously described TBL1 target pathway may be of minor relevance for TBL1-dependent tumorigenesis in PDAC as compared with other tumor entities and the significant regulatory function of TBL1 for the PI3 kinase signaling pathway. This evidence concerns the gene TBL1Y and neoplasm.