Indeed, an initial TBL1 chromatin immunoprecipitation coupled to massive parallel sequencing (ChIP-Seq) analysis in mouse liver identified a TBL1-binding site within the p110α PI3 kinase gene regulatory region (Supplementary Fig S8), and subsequent ChIP PCR studies using Capan-1 cells confirmed the recruitment of TBL1 to the p110α PI3 kinase gene promoter in pancreatic cancer cells (Fig3C). The gene discussed is TBL1Y; the disease is familial pancreatic carcinoma.