In the overall data, the area under curve (AUC) was 0.515 and the cutoff value of 1.42 μg/ml of HMW adiponectin (J: 0.039) significantly discriminated the cases from controls (P = 0.024, OR = 0.815, 95%CI, 0.682–0.973) after adjusting for menopause and family history of breast cancer (Table 3). The gene discussed is ADIPOQ; the disease is breast cancer.