ADIPOQ and hereditary pheochromocytoma-paraganglioma: More importantly, for cancers, HMW adiponectin were three times higher in patients with pheochromocytoma than in controls, yet lower HMW adiponectin was an independent risk factor for worse hepatocellular carcinoma histological grades and HMW adiponectin was decreased in patients with metastatic renal cancer compared with those with localized one.