In this sense, we investigated if phorbol ester (PMA), a potent tumor promoter that mimics diacylglycerol (DAG) in activation of PKC [40], and calphostin C, a specific and potent inhibitor of PKC [41,42], were able to modulate heme-dependent activation of Na+/K+ ATPase activity and the increase of H2O2 production. Here, PRRT2 is linked to neoplasm.