KCNA3 and torsades de pointes: Recent genome-wide association studies suggest promising insights into the understanding and predisposition of drug-induced LQT: whole exome sequencing analysis implicates an increased burden of multiple rare potassium channel variants in the risk of developing fatal TdP.[28, 29] It remains to be determined whether the search for genetic polymorphisms or rare variants might be cost-effective in some high-risk individuals and, possibly, generalized to larger scale.