To further demonstrate that FBP1 is a critical target gene involved in the NPM1-induced phenotypes of pancreatic cancer cells, we over-expressed FBP1 and NPM1 in the Bxpc-3 cell lines, and effective restoration of FBP1 expression in Bxpc3 cells was confirmed by qRT-PCR. The gene discussed is NPM1; the disease is familial pancreatic carcinoma.