NPM1 and familial pancreatic carcinoma: To further examine whether NPM1 can affect the glucose metabolism in pancreatic cancer cells, we measured glucose uptake and found that knock-down of NPM1 significantly decreased glucose uptake in Panc-1 and Aspc-1 cell lines (Figure 3A), whereas over-expression of NPM1 enhanced glucose uptake in the Bxpc-3 cell line (Figure 3C).