Although the study by Tanwar and colleagues [22] implicates loss of Lkb1 function in the initiation of ovarian cancer, genetic ablation was performed in the ovarian surface epithelium and not the secretory epithelium of oviduct; the secretory epithelium of the distal fallopian tube is now considered the site of origin for high-grade serous ovarian cancer [53, 54]. Here, STK11 is linked to ovarian serous adenocarcinoma.