Oncogenic activation of the TLR/IL1R pathway is found in several B-cell lymphomas, often in conjunction with the MYD88 L265P gain of function mutation [15] and 100% of primary effusion lymphoma harbor IRAK1 gain of function mutations leading to constitutive IRAK1 activation [16]. The gene discussed is IRAK1; the disease is B-cell non-Hodgkin lymphoma.