In order to confirm these data, we then performed assays with a broader range of dexamethasone doses tested on a p-IRAK positive (Jurkat) and a p-IRAK negative (HPB-ALL) T-ALL cell line with simultaneous genetic knockdown of IRAK-1 using shRNA544 (Figure 4C). This evidence concerns the gene IRAK1 and acute lymphoblastic leukemia.