Malignant mesothelioma (MM) is an aggressive cancer that arises from the neoplastic transformation of mesothelial cells lining the pleural, peritoneal, and pericardial cavities.1 In the United States, ~3200 individuals are diagnosed annually with MM and a similar number dies of this almost invariably fatal disease.1 Major risk factors for MM are exposure to asbestos and erionite mineral fibers and germline BAP1 mutations.1, 2. The gene discussed is BAP1; the disease is Miyoshi myopathy.