Although MM is the most well-characterized HMGB1-related tumor model,7 the relevance of extracellular HMGB1 to carcinogenesis has also been proposed in other inflammation-related malignancies.8 Recent data indicate that HMGB1 initiates a chain of events that promotes tumor metastasis in melanoma,9 a malignancy that shares some common molecular pathogenetic mechanisms with MM.2 HMGB1 levels in blood are elevated in MM,7, 10 and in several other inflammation-related cancers.11, 12. This evidence concerns the gene HMGB1 and neoplasm.