These post-translational steps generally occur after phosphorylation of Mcl-1 and/or interaction with NOXA, most likely not a major regulator here.36 In addition, Mcl-1 is the one of the Bcl-2 family proteins mostly affected by metabolic alterations.37, 38, 39 As CGs, including UNBS1450, were shown to induce autophagy and cytostatic effects,3, 40 Mcl-1 modulation might become an interesting indicator of other anti-cancer (anti-metabolic)? The gene discussed is PMAIP1; the disease is cancer.