MCL1 and cancer: In this study, we challenged this hypothesis by studying the modulatory effects of a panel of CGs, including both cardenolides (UNBS1450, ouabain, digitoxin and digoxin) and bufadienolides (cinobufagin and proscillaridin A) on Mcl-1 with a panel of human adherent and non-adherent cancer cell models of different origins.