Quantitative RT-PCR further confirmed that ICAM-1 deficiency significantly upregulated mRNA levels of IL-10, TGF-β, chemokine (C–C motif) ligand 17 (CCL17), CCL22 (M2-specific cytokines or chemokines) in hepatic metastatic tumors (Supplementary Figure 3). Here, TGFB1 is linked to metastatic neoplasm.