ICAM1 and colorectal carcinoma: Supplementary Figure 1a depicts the levels of ICAM-1 transcripts across four independent published microarray studies.37, 38, 39, 40 Furthermore, in a meta-analysis of recent gene expression profiling, increased ICAM-1 expression was significantly associated with colorectal carcinoma compared with normal (Supplementary Figure 1b). Notably, the box plot data from pathology subtyping within the Kaiser data set showed a lower log2 median expression of ICAM-1 in distant metastasis-positive colorectal carcinoma samples (0.595) compared with non-distant metastasis (0.782; Supplementary Figure 2).