Significant DNA hypomethylation was observed in preeclampsia for steroidogenic genes, including CYP11A1 for cytochrome P450scc and HSD3B1 for 3β-hydroxy-delta-5-steroid dehydrogenase type 1, each controlling the two-step pathway of progesterone synthesis from cholesterol [93]. The gene discussed is HSD3B1; the disease is preeclampsia.