Moreover, as previously proposed, the genomic abnormalities in IDHmut-1p/19p co-deleted tumours are consistent with one common mechanism of tumour initiation being through 1p/19q loss, mutation of IDH1 or IDH2 and TERT activation through promoter mutation2, which in turn predisposes to deactivation of CIC, FUBP1, NOTCH and activating mutations/amplifications in the PI3K pathway. The gene discussed is IDH2; the disease is neoplasm.