NFKB1 and brain disorder: In the present study, we set out to investigate whether autophagy is involved in the physiopathology of brain disorder occurring with sepsis and whether NF-κB signaling pathways modulate the autophagic capacity of hippocampal cells during sepsis by using pretreatment with the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC).