HNRNPU and neoplasm: Interestingly, although total p120 was relatively unaltered in tumor samples compared to normal when using the 15D2 or F1aSH antibodies, staining with the pp120 antibody resulted in significantly less or absent p120 staining in tumor samples (Fig 1A–1C), Quantification of the signal obtained from pp120, Y228 and 15D2 IHC confirmed that although the 15D2 staining intensity is similar between normal and tissue samples, the pp120 signal is dramatically decreased and the Y228 signal is inversely increased in tumor samples (Fig 1D).