Of the mice inoculated with 100 pfu (1 MLD50) influenza H1N1 virus and treated with anti-HMGB1 mAb (2 mg/kg, intravenously), 93.3 % were protected from influenza-induced death, whereas 53.3 % of infected mice administered control mAb died (Fig. 1a). This evidence concerns the gene HMGB1 and influenza.