CYP19A1 and breast cancer: Ferradelschi et al. [41] examined TTF in 308 women with metastatic BC treated with AIs, including 56 variants of CYP19A1. Patients carrying the rs4775936 T allele were found to exhibit significantly increased TTF relative to patients with the reference allele (HR, 0.79 [95 % CI, 0.66–0.95], P = 0.012).