In UBE3C-modified glioma cells and the corresponding control cells, we found that downregulation of UBE3C led to increased ANXA7 protein expression, whereas it had no effect on ANXA7 mRNA expression, although knockdown of ANXA7 had little influence on UBE3C expression (Fig. 4E,F). This evidence concerns the gene UBE3C and central nervous system cancer.