CLDN1 and breast cancer: We further examined the alteration of CLDN1 from six different datasets including breast invasive carcinoma (Broad, Sanger, TCGA, British Columbia, Nature, 2012 ) and breast cancer patient xenograft (Nature, 2014) and found that CLDN1 was amplified among samples collected in TGCA and patient xenograft dataset (Figure 1B).