TIMP1 and Chronic colitis: Recalling the intermediate effects of gelE deficiency in E. faecalis on chronic colitis in the IL-10-/- mouse model [20], GelE can be considered as a factor contributing to, but not sufficient for colitogenic activity of E. faecalis. In contrast, the loss of E. faecalis cell surface-associated lipoproteins resulted in almost complete abrogation of intestinal pathology, despite the presence of both Epa and GelE.