Indeed, TMEM16A was reported to be overexpressed in some malignant tumors and was known by different names, such as DOG1 (Discovered On Gastrointestinal stromal tumor protein 1 [19–20]), TAOS2 (Tumor Amplified and Overexpressed Sequence 2 [21]) overexpressed in oral squamous cell carcinomas, and ORAOV2 (Oral Cancer Overexpressed 2 [22]) overexpressed in oral and esophageal squamous cell carcinomas. The gene discussed is ANO1; the disease is esophageal squamous cell carcinoma.