In addition, multiple logistic regression analysis showed that plasma PAI-1 concentrations were associated with higher mortality at 30 days (Odds Ratio = 1.01; 95% CI = 1.002–1.022; p = 0.02) and at 6 months (Odds Ratio = 1.01; 95% CI = 1.003–1.023; p = 0.01), after controlling for diabetes mellitus, ischemic heart disease, COPD, age, SOFA score and serum lactic acid concentrations (Tables 3 and 4). The gene discussed is SERPINE1; the disease is chronic obstructive pulmonary disease.