To explore the catabolic pathways, we evaluated two genes encoding for two muscle-specific ubiquitin ligases, MuRF-1 (Muscle-Ring Finger-1) and atrogin-1, which play a critical role in proteasome-dependent muscle proteolysis [41] and that are up-regulated in various conditions of muscle atrophy, including HU. The gene discussed is FBXO32; the disease is Atrophy.